Development of a web application
to represent models of calcium and
phosphate homeostasis using R

Dr. David Granjon

About Me

2011-2013

Master’s degree
Université Claude Bernard Lyon

Mathematics and Computer Sciences
2013-2016

PhD in Life Sciences
Université Pierre et Marie Curie and Université de Lausanne

Thesis Title: «Modeling of Calcium and Phosphate Homeostasis in the Rat and its perturbations»
2016-2019

PostDoc Researcher
Université de Lausanne and University of Zurich

Develop web applications, package HTML templates into reusable R APIs, virtual machines management, design relevant educational content.

Graduate

Dashboard

Current Position

Principal Scientific Computing and Consulting, SCC, Novartis

Maintain AVA Templates.

Package HTML templates into reusable R APIs, design relevant educational content around ava (webinars, cheatsheets, ...).
Support Clinical Projects.

Develop Shiny apps for exploratory analysis, safety and efficacy
Internal Consulting.

Provide advises to Novartis associates

Interface Development for Ca-P eLearning

Model Overview

Model Features

94⁺ parameters
20⁺ variables
100⁺ equations (ODE)

https://www.ncbi.nlm.nih.gov/pubmed/27358053

https://www.ncbi.nlm.nih.gov/pubmed/28747359

Make it an eLearning Tool

Virtual patient app code

Making-of

Extend Shiny

shinyHex

Shiny is a reactive web-framework
allowing to create insightful applications
in minutes.

About RinteRface (https://rinterface.com)

RinteRface, a comprehensive set of UI APIs for Shiny

rinterfaceHex

Modularization, Packaging and CI

golemHex

devtoolsHex

Toward reliable code
Comprehensive Documentation
Foster collaboration
Increase productivity

code

The Interactive Network

See https://www.ncbi.nlm.nih.gov/pubmed/28747359

Effective visualization to get better insights

https://github.com/datastorm-open/visNetwork

Performance Optimization

Whenever R code is slow...

Rcode

... do it in C or C++

cCode

AppsPhysiol

Apps.Physiol

eLearning platform for physiology

Innovative eLearning plug and play solution
Seamlessly translate to research
https://github.com/DivadNojnarg/CaPO4Sim

mobileApp

shinyMobile

Toward Mobile Friendly Shiny Apps

Available on CRAN

https://github.com/RinteRface/shinyMobile
3 layouts

Develop apps for cellphones, tablets or desktop
3 skins and 2 gobal color themes

Custom widgets for iOS, android and desktop, with light or dark global theme
Launch app directly from your apps menu

Create custom icon and start screen to cutomize your app

shinyMobile virtual patient

Thank you!

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